NaviSuite®

Advanced Navigation for Image-Guided Interventions

Based on proprietary, undisclosed MedCom technology

NaviSuite® Virtual Navigator combines two imaging modalities — real-time ultrasound scanning and static cross-sectional imaging such as MR or CT — bringing them together in dynamic 2D and 3D navigation views. Targets are clearly visualized and instruments are tracked in real time.

From biopsy and interventional procedures to fusion-based workflows in urology, breast, and liver, NaviSuite® helps clinicians work with greater precision, confidence, and control. Intuitive, reliable, and clinically proven, NaviSuite® keeps ultrasound and second modality in precise alignment through fusion imaging and tracking — for confident diagnosis and accurate instrument placement.

With NaviSuite® Fusion Imaging and Tracking System, clinicians achieve precise alignment of Ultrasound with MR/CT images — improving accuracy in diagnosis and interventional procedures across multiple imaging modalities

NaviSuite® modalities

Brain

For brain applications, NaviSuite® fuses live ultrasound with CT or MR in both 2D and 3D navigation views. Clinicians can assess anatomy in context and guide instruments — such as the Virtual Pointer — with greater precision and control

Breast – BreastNavi®

Provides two separate workflows: an ultrasound only workflow for breast scanning and a data fusion workflow which allows combining an MR acquisition with live ultrasound data for precise lesion localization. Suspicious findings are reliably mapped and biopsies are planned and performed with image-guided confidence

Liver – LiverNavi®

LiverNavi® supports liver workflows from lesion detection to image-guided intervention. CT or MR data is fused with real-time ultrasound — including contrast-enhanced imaging — for confident target localization and precise procedural guidance

Prostate – UroFusion®

UroFusion® registers prostate MR with 3D ultrasound to support targeted biopsy of suspicious regions — including TRUS and stepper-guided systematic sampling. Prostate modelling, biopsy region planning, and instrument guidance come together in one navigation workflow for more precise diagnostics and controlled intervention

NaviSuite® main tasks

Technology Licensing & Partnerships

NaviSuite®, developed by MedCom, is a powerful image fusion and navigation platform now licensed to Esaote and integrated into its ultrasound systems for use across various clinical specialties

Overlap CT over US
Overlap US over CT
Overlap Edge

Virtual navigator history

The idea

The Inspiration Behind Navisuite®

NaviSuite® came into existence as a result of an innovative idea that was born and nurtured to fruition.

Introduction

RSNA 2004 CD Presentation

Real-Time ultrasound CT fusion:
How to quickly and precisely perform radiofrequency ablation for small or poorly visualized liver tumors (Solbiati-Cova-Ierace)

Virtual Needle

RSNA 2005

New improvement of Real-time US: CT Fusion-
The anatomical markers and the “Virtual Needle” (Solbiati-Cova-Bellobuono)

The Planning

CIRSE 2006: Gruntzig Lecture
Image – guidance propelling the future of cancer therapy (Solbiati)

RSNA 2006
Real-time CT/US fusion imaging for the guidance of ablative treatment of small hepatic, renal and adrenal malignancies.

(Solbiati-Cova-Ierace-De Beni)

MyLab70XVG New

RSNA 2007
Use of Real-time US/CT fusion imaging as simulation device for teaching how to safely and precisely perform sonographically-guided interventional procedures (Solbiati, Ierace, De Beni)

Motion sensor

European Patent 01ESA12-EP

Further innovations

  • Automatic Registration (Patent Pending)
  • Respiratory Gating
  • Auto-Segmentation Of Lesions
  • Multimodality Dataset Rigid Registration
Specific Requirements

  • 2D Navigation
  • Neuronavigation Environment
  • TAVI Puncture Environment

Automatic Registration In Transcranial Application

Dedicated Workflow Navigation Protocols For Abdominal, Urology, Neurosonology, And Neurosurgery Procedure

MyLab LION

  • Urology And TRUS Protocols And The Possibility To Mount US Probe On The Stepper
  • User Interface And Architecture Adjustment For Full Integration On New ESAOTE LION Device

Breast Navigation Module – US<->US Only Including Breast Scanning Coverage, Targets Definition, 3D US Review After Scanning, Pre-Post Examination Comparison

  • Breast Navigation Extended To US<->MR And US<-> Mammography Using Deformation Model Do Adjust The Dataset To The Current Shape Of The Examined Breast. On The Fly
  • Adjustments Are Applied During The Scanning Of Further Deform
  • Urology: Automated Prostate Zones Definition, Extended URO Reporting Including Insertions Zones And Coverage Indications
  • Urology: Automated Model-Based Prostate Contouring Mode (Patented)
  • Breast Navigation: More Accurate Breast Deformation Algorithm

Augmented Reality View Including Overlapping Of The Probe, Probe Plane, Needle, Targets And, Insertions Over Real Patient Video

  • Fully Automatic Abdominal Registration Using 3D Camera (Patent Pending)

Latest scientific literature on NaviSuite®

E Martorana, M Cristina Aisa, R Grisanti, N Santini, G Maria Pirola, A Datti, S Gerli, A Bonora, A Burani, G Battista Scalera, P Scialpi, A Di Blasi, M Scialpi

Lesion Volume in a Bi- or Multivariate Prediction Model for the Management of PI-RADS v2.1 Score 3 Category Lesions

Rinaldi, Marco; Di Lena, Sebastiano

Are there Detection Rate Differences of Transperineal Freehand US/MRI Fusion Target Prostate Biopsy in Two Different Patient Settings: Under Local Anesthesia or Under Deep Sedation?

Görtz, Magdalena; Nyarangi-Dix, Joanne; Pursche, Lars; Schütz, Viktoria; Reimold, Philipp; Schwab, Constantin; Stenzinger, Albrecht; Sültmann, Holger; Duensing, Stefan; Schlemmer, Heinz-Peter; Bonekamp, David; Hohenfellner, Markus; Radtke, Jan

Impact of Surgeon’s Experience in Rigid versus Elastic MRI/TRUS-Fusion Biopsy to Detect Significant Prostate Cancer Using Targeted and Systematic Cores

Angelo Naselli, Isabella Oliva, Nikolaos Papanikolau, Elisabetta Uslenghi, Roberta Trevisan, Andrea Guarneri

Fusion prostate biopsy: tips and tricks to improve rigid registration

Brunner, Cornelia; Schreiber, Stephan Joachim; Bokemeyer, Martin; Ransmayr, Gerhard; Struhal, Walter; Olbert, Elisabeth Daniela; Alhani, Naela; Vosko, Milan Rastislav

Value of ultrasound fusion imaging in detecting vascular cerebral white matter pathology

Qi, Ruixiang; Fang, Jianhua; Zhu, Luoxi; Shan, Yanna; Wang, Wei; Xu, Chenke; Bao, Lingyun

Prospective Evaluation of Ultrasound in a Novel Position with MRI Virtual Navigation for MRI-Detected Only Breast Lesions: A Pilot Study of a More Efficient and Economical Method

Marco Rinaldi, Sebastiano Di Lena

Transperineal Freehand US/MRI Fusion Target Prostate Biopsy using the Esaote Mylab 9 System: A Step by Step Guide

Esaote S.p.A. – sole-shareholder company (English)

UroFusion TPUS/TRUS Smart Prostate Target Biopsy June 2022, Genova, Italy

G Calleris, A Marquis, J Zhuang, M Beltrami, X Zhao, Y Kan, M Oderda, H Huang, R Faletti, Q Zhang, L Molinaro, W Wang, H Guo, P Gontero, G Marra

Impact of operator expertise on transperineal free-hand mpMRI-fusion-targeted biopsies under local anaesthesia for prostate cancer diagnosis: a multicenter prospective learning curve

Hu, Beibei; Zhang, Huili; Zhang, Yueyue; Jin, Yongming

FI-CEUS: A nomogram based on biparametric magnetic resonance imaging for detection of clinically significant prostate cancer in biopsy-naïve patients


Qingjing Zeng, Sidong Xie, Xuqi He, Yuefei Guo, Yuxuan Wu, Na He, Lanxia Zhang, Xuan Yu, Rongqin Zheng, Kai Li

FI-CEUS: a solution to improve the diagnostic accuracy in MRI LI-RADS-indeterminate (LR-3/4) FLLs at risk for HCC. 2023


Gilberto, Guilherme Moratti; Arcuri, Marcelo Froeder; Falsarella, Priscila Mina; Mariotti, Guilherme Cayres; Lemos Neto, Pedro Lemos Alves; Garcia, Rodrigo Gobbo

Complication rates of transrectal and transperineal prostate fusion biopsies – is there a learning curve even in high volume interventional center. 2023


Manenti, Guglielmo; Nezzo, Marco; Ryan, Colleen Patricia; Fraioli, Federico Romeo; Carreri, Beatrice; Gigliotti, Paola Elda; Angeloni, Cecilia; Di Pietro, Francesca; De Angeli, Martina; Perretta, Tommaso; D’Angelillo, Rolando Maria; Garaci, Francesco Giuseppe

Transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer. 2023


Jian-Hua Fang, Liqing Zhang, Xi Xie, Pan Zhao, Lingyun Bao, Fanlei Kong

Comparative diagnostic accuracy of multiparametric magnetic resonance imaging-ultrasound fusion-guided biopsy versus systematic biopsy for clinically significant prostate cancer, 2023

Marco Rinaldi, Sebastiano Di Lena

Should a Targeted Prostate Biopsy be Performed for Every PIRADS 3 Lesion Found on Multiparametric MRI of the Prostate?

Albano, Domenico; Messina, Carmelo; Gitto, Salvatore; Fusco, Stefano; Sconfienza, Luca Maria; Bellelli, Alberto

US/CT fusion imaging and virtual navigation to guide lumbar intradiscal oxygen-ozone therapy: a pilot study, 2023


Xu, Guang; Li, Jun-Heng; Xiang, Li-Hua; Yang, Bin; Chen, Yun-Chao; Sun, Yi-Kang; Zhao, Bing-Hui; Wu, Jian; Sun, Li-Ping; Xu, Hui-Xiong

Transrectal ultrasound examination of prostate cancer guided by fusion imaging of multiparametric MRI and TRUS: avoiding unnecessary mpMRI-guided targeted biopsy, 2023


Pragati Rai, Mohammed Yusuf Ansari, Mohammed Warfa, Hammad Al-Hamar, Julien Abinahed, Ali Barah, Sarada Prasad Dakua, Shidin Balakrishnan

Efficacy of fusion imaging for immediate post-ablation assessment of malignant liver neoplasms: A systematic review, 2023

FeiFei Shan, JunQi Sun

MRI/ULTASOUND FUSION INCREASE DIAGNOSTIC ACCURACY OF BREASTLESION, China 2024

Jing Wen, Wei Liu, Xiaocui Shen, Wei Hu

PI-RADS v2.1 and PSAD for the prediction of clinically significant prostate cancer among patients with PSA levels of 4–10 ng/ml


Wei Li, Haibing Xu, Wenwen Shang, Guohui Hong

Comparisons of three scoring systems based on biparametric magnetic resonance imaging for prediction of clinically significant prostate cancer. 2024


Martina Paccini1 · Giacomo Paschina2 · Stefano De Beni2 · Andrei Stefanov3 · Velizar Kolev3 · Giuseppe Patanè1

US & MR/CT Image Fusion with Markerless Skin Registration: A Proof of Concept. 2024

Qingjing Zeng, Sidong Xie, Xuqi He, Yuefei Guo, Yuxuan Wu, Na He, Lanxia Zhang, Xuan Yu, Rongqin Zheng, Kai Li

FI-CEUS: a solution to improve the diagnostic accuracy in MRI LI-RADS-indeterminate (LR-3/4) FLLs at risk for HCC

Fabio M. Doniselli, Riccardo Ciocca, Domenico Aquino, Marina Grisoli, Massimiliano Del Bene, Stefania Ferraro, Giovanni Durando, Luca Raspagliesi, Frederic Padilla, Luca Maria Sconfienza, Francesco DiMeco and Francesco Prada

Cerebral microbubble distribution correlation between preoperative perfusion MRI and intraoperative contrast enhanced ultrasound

M Oderda, G Calleris, A Dematteis, A Greco, A Marquis, G Marra, U Merani, A Sasia, A Venturi, A Zitella, P Gontero

Transperineal Free-Hand Prostate Fusion Biopsy with AI-Driven Auto-Contouring: First Results of a Prospective Study

LiverNav

PROJEKTBESCHREIBUNG Ziel des Vorhabens ist, ein Navigationssystem für die offene Leberchirurgie zu entwickeln. Das Navigationssystem soll den Chirurgen bei der Durchführung der offenen Leberchirurgie unterstützen. Es soll zwei bildgebende Modalitäten mit Hilfe von sog. fusion imaging in Echtzeit im OP-Saal verbinden.